Hausmann R, Vogel C, Seidl S, Betz P
Institute of Legal Medicine, University of Erlangen-Nürnberg, Universitätsstrasse 22, 91054 Erlangen, Germany.
Int J Legal Med. 2006 Jul;120(4):219-25. doi: 10.1007/s00414-005-0021-6. Epub 2005 Jul 30.
This study investigated the value of both gross features and histological findings for grading of brain swelling. For this purpose, the grooving of the temporal gyri (unci) as well as the extension of the cones at the basal part of the cerebellum were measured in 42 brains obtained at autopsy. Furthermore, the distension of perivascular spaces in tissue samples from seven different regions of the brains was evaluated histologically, assisted by an automatic image processing and analysis system. In each individual, the normal range of brain weight was calculated on the basis of the body height, using the formulae by Röthig and Schaarschmidt. The difference between this calculated (normal) value and the brain weight evaluated at autopsy was considered as a reliable criterion for the grade of brain swelling. There was no statistical evidence of a positive correlation between the various parameters. Hence, it can be concluded that both gross section and histological findings are of minimal significance for grading of brain swelling.
本研究调查了大体特征和组织学结果在脑肿胀分级中的价值。为此，在42例尸检获得的大脑中测量了颞回（钩）的沟回以及小脑底部锥体的延伸情况。此外，借助自动图像处理和分析系统，对来自大脑七个不同区域的组织样本中的血管周围间隙扩张情况进行了组织学评估。在每个个体中，根据身高使用Röthig和Schaarschmidt的公式计算脑重量的正常范围。将该计算出的（正常）值与尸检时评估的脑重量之间的差异视为脑肿胀分级的可靠标准。没有统计学证据表明各种参数之间存在正相关。因此，可以得出结论，大体切片和组织学结果在脑肿胀分级中的意义极小。
