Lau Y L, Jones B M, Yeung C Y
Department of Paediatrics, Queen Mary Hospital, University of Hong Kong.
J Paediatr Child Health. 1992 Jun;28(3):240-3. doi: 10.1111/j.1440-1754.1992.tb02654.x.
A study was conducted on 751 healthy children from child health clinics, kindergartens and schools, and 80 normal adults to establish reference ranges for serum immunoglobulins (Ig) G, A and M concentrations in normal Chinese. Serum IgG, IgA and IgM concentrations were determined by nephelometry. Serum IgG and IgA were shown to have a significant rise during the preschool age as well as at puberty with a plateau phase in between. This biphasic maturation profile has not been reported in Caucasians and the reasons for the observed difference have yet to be elucidated. Serum IgM concentrations were shown to be higher in females than in males, reaching significance in most age groups beyond 4 years of age. The difference between the two sexes in Chinese was of similar magnitude as that reported for Blacks and Caucasians, that is, 30%. Our findings support the hypothesis that the human X chromosome may carry quantitative genes for IgM.
对来自儿童健康诊所、幼儿园和学校的751名健康儿童以及80名正常成年人进行了一项研究，以建立中国正常人群血清免疫球蛋白（Ig）G、A和M浓度的参考范围。采用散射比浊法测定血清IgG、IgA和IgM浓度。结果显示，血清IgG和IgA在学龄前以及青春期有显著升高，中间有一个平稳期。这种双相成熟模式在白种人中尚未见报道，观察到的差异原因尚待阐明。血清IgM浓度显示女性高于男性，在4岁以上的大多数年龄组中具有统计学意义。中国人两性之间的差异幅度与黑人和白种人报道的相似，即30%。我们的研究结果支持这样的假设，即人类X染色体可能携带IgM的数量基因。
