Kardar G A, Shams S H, Pourpak Z, Moin M
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, I.R., Iran.
J Immunoassay Immunochem. 2003;24(4):359-67. doi: 10.1081/IAS-120025774.
Local reference ranges of immunoglobulins are required for studies and clinical interpretation. In this study, serum levels of IgA, IgG, and IgM in 914 Iranian healthy adult blood donor volunteers, aged 18-55 years, were measured by nephelometry. Our data showed that serum reference intervals of IgA, IgG, and IgM in subjects were 72-375, 636-1518, and 39-283 mg/dL, respectively. Data analysis showed a significant difference between the male and female subjects only for IgM; thus, the means of IgM in females were higher than for males (p < 0.05). Correlation coefficient r for paired samples showed no statistically significant relationship between age and each Ig (p > 0.05). Comparison of this study with others demonstrated that results are similar; some differences are probably related to ethnic differences. Therefore, our results can be considered as a source of reliable local reference for use in laboratories.
免疫球蛋白的本地参考范围对于研究和临床解读是必需的。在本研究中，通过散射比浊法测量了914名年龄在18至55岁的伊朗健康成年献血志愿者的血清IgA、IgG和IgM水平。我们的数据显示，受试者中IgA、IgG和IgM的血清参考区间分别为72 - 375、636 - 1518和39 - 283 mg/dL。数据分析表明，仅IgM在男性和女性受试者之间存在显著差异；因此，女性的IgM均值高于男性（p < 0.05）。配对样本的相关系数r显示年龄与每种免疫球蛋白之间无统计学显著关系（p > 0.05）。本研究与其他研究的比较表明结果相似；一些差异可能与种族差异有关。因此，我们的结果可被视为实验室使用的可靠本地参考来源。
