Takahashi H, Wada K, Hanano M, Niwano H, Takizawa S, Yazawa Y, Shibata A
First Department of Internal Medicine, Niigata University School of Medicine, Japan.
Blood Coagul Fibrinolysis. 1992 Apr;3(2):193-6. doi: 10.1097/00001721-199204000-00009.
In order to assess the fibrinolytic state in thrombotic disease, plasma levels of fibrin degradation products (FbDP) and fibrinogen degradation products (FgDP) were measured in 126 patients with a variety of thrombotic diseases. Mean plasma concentrations of both FbDP and FgDP were significantly elevated in patients with thrombotic disease as compared with healthy subjects. Plasma concentrations of FgDP were positively correlated with FbDP (r = 0.667, P less than 0.001). When analysed according to the disease categories, the magnitude of elevations of FbDP and FgDP was most prominent in venous thrombotic disease such as deep vein thrombosis and pulmonary embolism. These findings indicate that fibrinolysis is accelerated in patients with thrombotic disease and that fibrinolysis is frequently accompanied by some fibrinogenolysis in these patients.
为了评估血栓性疾病中的纤溶状态，我们检测了126例患有各种血栓性疾病患者的血浆纤维蛋白降解产物（FbDP）和纤维蛋白原降解产物（FgDP）水平。与健康受试者相比，血栓性疾病患者的FbDP和FgDP平均血浆浓度均显著升高。FgDP的血浆浓度与FbDP呈正相关（r = 0.667，P < 0.001）。根据疾病类别进行分析时，FbDP和FgDP升高的幅度在静脉血栓性疾病如深静脉血栓形成和肺栓塞中最为显著。这些发现表明，血栓性疾病患者的纤溶加速，并且在这些患者中纤溶常伴有一些纤维蛋白原溶解。
