Rifón J, Fernández J, Páramo J A, Cuesta B, Rocha E
University Clinic, University of Navarra, Pamplona, Spain.
Blood Coagul Fibrinolysis. 1990 Oct;1(4-5):509-12. doi: 10.1097/00001721-199010000-00027.
We have determined fibrinogen and fibrin degradation products (FgDP and FbDP respectively) by an ELISA method using specific monoclonal antibodies in 100 patients undergoing cardiopulmonary bypass (CPB) for valvular heart disease and in 60 patients undergoing aorto-coronary bypass surgery. Blood samples were taken pre-operatively and on post-operative days 1 and 5. Post-operative evolution was similar in both patient groups, with a significant increase in FgDP on post-operative days 1 and 5 with respect to baseline value (P less than 0.01). FbDP were also significantly higher on post-operative days 1 and 5 (P less than 0.001), especially the day after surgery in patients with valvular disease as compared with coronary patients (P less than 0.01). Our results indicate that fibrinolysis is more important than fibrinogenolysis after open-heart surgery, which may have pathophysiological implications.
我们采用酶联免疫吸附测定法（ELISA），使用特异性单克隆抗体，对100例接受瓣膜性心脏病体外循环（CPB）手术的患者以及60例接受主动脉冠状动脉搭桥手术的患者，分别测定了纤维蛋白原和纤维蛋白降解产物（分别为FgDP和FbDP）。术前及术后第1天和第5天采集血样。两组患者术后的病情发展相似，术后第1天和第5天FgDP相对于基线值显著升高（P＜0.01）。术后第1天和第5天FbDP也显著升高（P＜0.001），尤其是瓣膜病患者术后第1天与冠心病患者相比更高（P＜0.01）。我们的结果表明，心脏直视手术后纤溶作用比纤维蛋白原溶解更为重要，这可能具有病理生理学意义。
