Horimoto Taisuke, Kawaoka Yoshihiro
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Nat Rev Microbiol. 2005 Aug;3(8):591-600. doi: 10.1038/nrmicro1208.
Recent outbreaks of highly pathogenic avian influenza A virus infections (H5 and H7 subtypes) in poultry and in humans (through direct contact with infected birds) have had important economic repercussions and have raised concerns that a new influenza pandemic will occur in the near future. The eradication of pathogenic avian influenza viruses seems to be the most effective way to prevent influenza pandemics, although this strategy has not proven successful so far. Here, we review the molecular factors that contribute to the emergence of pandemic strains.
近期，高致病性甲型禽流感病毒（H5和H7亚型）在家禽以及人类中（通过直接接触受感染禽类）爆发，造成了重大经济影响，并引发了人们对近期将发生新的流感大流行的担忧。根除致病性禽流感病毒似乎是预防流感大流行的最有效方法，尽管这一策略迄今尚未被证明是成功的。在此，我们综述了促成大流行毒株出现的分子因素。
