干扰素-α和地塞米松可抑制T细胞与内皮细胞及滑膜细胞的黏附。
Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells.
作者信息
Eguchi K, Kawakami A, Nakashima M, Ida H, Sakito S, Matsuoka N, Terada K, Sakai M, Kawabe Y, Fukuda T
机构信息
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
出版信息
Clin Exp Immunol. 1992 Jun;88(3):448-54. doi: 10.1111/j.1365-2249.1992.tb06470.x.
We investigated whether interferon-gamma (IFN-gamma), interferon-alpha (IFN-alpha) and glucocorticoids affected the adhesion of T cells to human umbilical endothelial cells or human synovial cells. About 30% of peripheral blood T cells could bind to unstimulated endothelial cells, but only a few T cells could bind to unstimulated synovial cells. When both endothelial cells and synovial cells were cultured with recombinant IFN-gamma (rIFN-gamma), the percentage of T cell binding to both types of cells increased in a dose-dependent manner. rIFN-alpha and dexamethasone blocked the T cell binding to unstimulated endothelial cells. Furthermore, rIFN-alpha and dexamethasone suppressed T cell binding to both endothelial cells and synovial cells stimulated by IFN-gamma, and also inhibited intercellular adhesion molecule-1 (ICAM-1) expression on both endothelial cells and synovial cells stimulated by IFN-gamma. These results suggest that IFN-alpha and glucocorticoids may inhibit T cell binding to endothelial cells or synovial cells by modulating adhesion molecule expression on these cells.
我们研究了γ干扰素（IFN-γ）、α干扰素（IFN-α）和糖皮质激素是否会影响T细胞与人脐静脉内皮细胞或人滑膜细胞的黏附。约30%的外周血T细胞可与未受刺激的内皮细胞结合，但只有少数T细胞能与未受刺激的滑膜细胞结合。当内皮细胞和滑膜细胞均用重组γ干扰素（rIFN-γ）培养时，T细胞与这两种细胞结合的百分比呈剂量依赖性增加。rIFN-α和地塞米松可阻断T细胞与未受刺激的内皮细胞的结合。此外，rIFN-α和地塞米松可抑制T细胞与IFN-γ刺激的内皮细胞和滑膜细胞的结合，还可抑制IFN-γ刺激的内皮细胞和滑膜细胞上细胞间黏附分子-1（ICAM-1）的表达。这些结果表明，IFN-α和糖皮质激素可能通过调节这些细胞上黏附分子的表达来抑制T细胞与内皮细胞或滑膜细胞的结合。
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