Stella F, Battistelli S, Marcheggiani F, De Santis M, Donnorso R P, Baronciani D, Durazzi S M, Troccoli R, Lucarelli G
Institute of Histology and Laboratory Analysis, University of Urbino, Italy.
Diagn Cytopathol. 1992;8(3):216-21. doi: 10.1002/dc.2840080306.
Since cyclophosphamide and busulphan used for therapy of bone marrow transplantation (BMT) can cause urothelial cell changes similar to those found in bladder cancer, comparative morphologic and morphometric urinary cytologic research was carried out, examining 812 urine samples taken from 121 patients undergoing BMT and 60 urine samples from 20 patients with bladder cancer. The morphological results showed some differences in the characteristics of the urinary sediment in urothelial toxicity caused by conditioning therapy in BMT and in bladder cancer; among these were background, cellularity, leukocytes, urothelial cell arrangement, cell shape and size, vacuolization, mitosis, and nucleoli. A comparative morphometric study was also carried out, showing differences regarding cell area, nuclear area and perimeter, and N/C ratio, especially between well-differentiated bladder cancer and urothelial toxicity.
由于用于骨髓移植（BMT）治疗的环磷酰胺和白消安可引起与膀胱癌中发现的类似的尿路上皮细胞变化，因此开展了一项比较形态学和形态计量学的尿液细胞学研究，检查了取自121例接受BMT患者的812份尿液样本以及20例膀胱癌患者的60份尿液样本。形态学结果显示，BMT预处理疗法和膀胱癌导致的尿路上皮毒性在尿沉渣特征方面存在一些差异；其中包括背景、细胞密度、白细胞、尿路上皮细胞排列、细胞形状和大小、空泡化、有丝分裂和核仁。还进行了一项比较形态计量学研究，结果显示在细胞面积、核面积和周长以及N/C比值方面存在差异，尤其是在高分化膀胱癌和尿路上皮毒性之间。
