Bell G D, Quine A, Antrobus J H, Morden A, Burridge S M, Coady T J, Lee J
Department of Medicine, Ipswich Hospital, Suffolk, United Kingdom.
Gastrointest Endosc. 1992 May-Jun;38(3):319-25. doi: 10.1016/s0016-5107(92)70424-6.
We have examined the efficacy of supplemental oxygen in preventing episodes of significant arterial desaturation (SpO2 less than 90%) during upper gastrointestinal endoscopy. We have compared the effects of 2 liters.min-1 of oxygen given orally via the bite-guard with the same flow rate via nasal cannulas and have also examined the effects of pre-oxygenation. Results of this study at a flow rate of 2 liters.min-1 have been compared with previously published results at a flow rate of 3 liters.min-1. Although in this study fewer episodes of desaturation were seen in the orally supplemented group compared with the nasal group, the difference observed was not statistically significant. Pre-oxygenation significantly reduced episodes of desaturation (SpO2 less than 90%, p less than 0.01) and prevented SpO2 falls below 85% in all patients studied. Supplemental oxygen given at a rate of 2 liters.min-1 was as effective as that given at a rate of 3 liters.min-1 in preventing significant desaturation, as previously defined, during the procedure. We therefore recommend the use of supplemental oxygen at a flow rate of 2 liters.min-1 in all high risk patients and conclude that the oral route has practical advantages and is at least as effective as nasal cannulas.
我们研究了补充氧气在预防上消化道内镜检查期间严重动脉血氧饱和度降低（脉搏血氧饱和度低于90%）发作方面的效果。我们比较了通过咬嘴以每分钟2升的流速经口给予氧气与通过鼻导管以相同流速给予氧气的效果，并且还研究了预充氧的效果。本研究中每分钟2升流速的结果已与先前发表的每分钟3升流速的结果进行了比较。虽然在本研究中，与鼻导管组相比，经口补充氧气组观察到的血氧饱和度降低发作较少，但观察到的差异无统计学意义。预充氧显著减少了血氧饱和度降低发作（脉搏血氧饱和度低于90%，P<0.01），并防止了所有研究患者的脉搏血氧饱和度降至85%以下。在预防先前定义的操作过程中严重血氧饱和度降低方面，以每分钟2升的流速给予补充氧气与以每分钟3升的流速给予同样有效。因此，我们建议在所有高危患者中使用每分钟2升流速的补充氧气，并得出结论，经口途径具有实际优势，且至少与鼻导管一样有效。
