Bell G D, Antrobus J H, Lee J, Coady T, Morden A
Department of Medicine, Ipswich Hospital, Suffolk, UK.
Aliment Pharmacol Ther. 1990 Aug;4(4):393-401. doi: 10.1111/j.1365-2036.1990.tb00485.x.
A total of 131 patients undergoing upper gastrointestinal endoscopy were sedated with midazolam given as a bolus injection over 5 seconds. The oxygen saturation was continuously measured using a pulse oximeter. Supplemental oxygen was given via nasal cannulae at a rate of 3 litres per minute to 54 patients, while the remaining 77 patients only received oxygen if their oxygen saturation dropped below 85%. Both groups in the present series were compared with 3 previously published series of patients, in whom we had used intravenous midazolam as a slow titrated injection. Despite using on average only two-thirds of the dose of midazolam, following bolus injection the degree of oxygen desaturation during the endoscopic procedure was greater, and the ability of supplemental oxygen delivered via nasal cannulae to prevent hypoxia was less (P less than 0.01), than with a slow titrated injection.
共有131例接受上消化道内镜检查的患者用咪达唑仑进行镇静，通过5秒钟的静脉推注给药。使用脉搏血氧仪连续测量血氧饱和度。54例患者通过鼻导管以每分钟3升的速率给予补充氧气，而其余77例患者仅在血氧饱和度降至85%以下时才接受氧气。本系列中的两组患者与之前发表的3组患者进行了比较，在之前的研究中我们使用静脉注射咪达唑仑进行缓慢滴定注射。尽管平均仅使用了三分之二剂量的咪达唑仑，但与缓慢滴定注射相比，推注给药后内镜检查过程中的氧饱和度下降程度更大，通过鼻导管输送补充氧气预防缺氧的能力更弱（P<0.01）。
