Stewart C J, Farquharson M A, Foulis A K
Department of Pathology, Royal Infirmary, Glasgow, UK.
Histopathology. 1992 Jun;20(6):491-7. doi: 10.1111/j.1365-2559.1992.tb01033.x.
The inflammatory infiltrate has been characterized in 10 cases of ovarian dysgerminoma using a panel of antisera to T-cells, B-cells and macrophages. The expression of Class II major histocompatibility complex (MHC) antigens and the distribution of interferons alpha and gamma were also examined. T-lymphocytes were present in all tumours, often closely admixed with neoplastic elements. T-cells in most areas were immunoreactive with gamma interferon. B-cells were generally scanty although germinal centres were present in three tumours. Immunocytochemistry revealed greater numbers of macrophages than had been appreciated on routinely stained sections. Macrophages were closely related to both lymphoid and tumour cells, and many macrophages were immunoreactive for alpha interferon. Class II MHC expression was mainly restricted to macrophages and B-cell areas although occasional T-cells were also stained. Dysgerminoma cells did not express Class II MHC antigens.
运用一组抗T细胞、B细胞和巨噬细胞的抗血清，对10例卵巢无性细胞瘤的炎性浸润进行了特征分析。同时还检测了II类主要组织相容性复合体（MHC）抗原的表达以及α干扰素和γ干扰素的分布。所有肿瘤中均存在T淋巴细胞，常与肿瘤成分紧密混合。大多数区域的T细胞对γ干扰素具有免疫反应性。B细胞通常较少，不过有3例肿瘤存在生发中心。免疫细胞化学显示，巨噬细胞的数量比常规染色切片中观察到的要多。巨噬细胞与淋巴细胞和肿瘤细胞都密切相关，许多巨噬细胞对α干扰素具有免疫反应性。II类MHC表达主要局限于巨噬细胞和B细胞区域，尽管偶尔也有T细胞被染色。无性细胞瘤细胞不表达II类MHC抗原。
