使用相位对比电影磁共振成像测量正常肾血流量。
Normal renal blood flow measurement using phase-contrast cine magnetic resonance imaging.
作者信息
Sommer G, Noorbehesht B, Pelc N, Jamison R, Pinevich A J, Newton L, Myers B
机构信息
Department of Radiology, Stanford University School of Medicine, California 94305.
出版信息
Invest Radiol. 1992 Jun;27(6):465-70. doi: 10.1097/00004424-199206000-00012.
RATIONALE AND OBJECTIVES
This study assesses the ability of a cardiac-gated phase-contrast magnetic resonance imaging (MRI) technique to measure renal blood flow (RBF) noninvasively in humans.
METHODS
In nine normal volunteers, total RBF in the renal arteries and in the left renal vein was estimated by MRI and correlated with RBF determined by the clearance of para-aminohippuric acid (CPAH) and the hematocrit level.
RESULTS
Correlation of RBF estimated from left renal vein flow, with RBF by CPAH-hematocrit, yielded r = .86 (P less than .003). Repeated measurement of RBF by MRI demonstrated a high degree of reproducibility, with coefficients of variation ranging from 4.8% to 8.9%. However, the MRI measurements of arterial flow did not significantly correlate with the standard measurements.
CONCLUSIONS
Reproducible noninvasive measurement of normal RBF is possible with the phase-contrast MRI technique used to measure renal venous blood flow.
原理与目的
本研究评估心脏门控相位对比磁共振成像（MRI）技术在人体中无创测量肾血流量（RBF）的能力。
方法
对9名正常志愿者，通过MRI估计肾动脉和左肾静脉的总RBF，并与通过对氨基马尿酸清除率（CPAH）和血细胞比容水平测定的RBF进行相关性分析。
结果
根据左肾静脉血流估计的RBF与通过CPAH-血细胞比容测定的RBF之间的相关性，r = 0.86（P < 0.003）。通过MRI重复测量RBF显示出高度的可重复性，变异系数范围为4.8%至8.9%。然而，动脉血流的MRI测量值与标准测量值无显著相关性。
结论
使用用于测量肾静脉血流的相位对比MRI技术可以对正常RBF进行可重复的无创测量。
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