Vivekanandhan S, Soundararajan C C, Tripathi M, Maheshwari M C
Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
Neurochem Res. 2005 Apr;30(4):453-6. doi: 10.1007/s11064-005-2680-6.
Multiple sclerosis (MS) is one of the most common causes of neurological disability in young and middle-aged adults and is thought to be mediated by autoreactive T cells. Activities of adenosine deaminase (ADA) and 5'(nucleotidase (5'NT), which are involved in the differentiation and maturation of the lymphoid system, were measured in peripheral blood T cells from 21 MS patients and in 23 age and sex matched healthy controls to determine whether an association existed between these enzyme abnormalities and cellular immune functions. ADA and 5'NT activities were found significantly decreased in MS patients (P < .001 and P < .01 respectively) when compared with controls. Low levels of ADA and 5'NT activities were found irrespective of whether patients had relapsing-remitting or chronic progressive MS. These findings suggest that low levels of these enzyme activities in T cells may be related to the persistent abnormalities in T cell function in the clinical course of MS.
多发性硬化症（MS）是年轻及中年成年人神经功能障碍最常见的病因之一，被认为是由自身反应性T细胞介导的。在21例MS患者及23例年龄和性别相匹配的健康对照者的外周血T细胞中，检测了参与淋巴系统分化和成熟的腺苷脱氨酶（ADA）和5'核苷酸酶（5'NT）的活性，以确定这些酶异常与细胞免疫功能之间是否存在关联。与对照组相比，MS患者的ADA和5'NT活性显著降低（分别为P < 0.001和P < 0.01）。无论患者是复发缓解型还是慢性进展型MS，均发现ADA和5'NT活性水平较低。这些发现表明，T细胞中这些酶活性水平较低可能与MS临床病程中T细胞功能的持续异常有关。
