Hafler David A
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
J Clin Invest. 2004 Mar;113(6):788-94. doi: 10.1172/JCI21357.
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
多发性硬化症是一种复杂的遗传性疾病，与中枢神经系统白质炎症相关，这种炎症被认为是由自身反应性T细胞介导的。在多发性硬化症中可发现B细胞、其抗体产物以及T细胞的克隆性扩增，这些都是中枢神经系统炎症的特征。本综述讨论了通过对种系DNA单倍型、RNA表达和蛋白质结构进行高通量检测来定义人类疾病分子病理学的新方法，这将有助于生成一系列新的假设，通过对这些假设进行验证，能更好地理解该疾病并开发相应的治疗方法。
