多发性硬化症
Multiple sclerosis.
作者信息
Hafler David A
机构信息
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Clin Invest. 2004 Mar;113(6):788-94. doi: 10.1172/JCI21357.
Abstract
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
摘要
多发性硬化症是一种复杂的遗传性疾病，与中枢神经系统白质炎症相关，这种炎症被认为是由自身反应性T细胞介导的。在多发性硬化症中可发现B细胞、其抗体产物以及T细胞的克隆性扩增，这些都是中枢神经系统炎症的特征。本综述讨论了通过对种系DNA单倍型、RNA表达和蛋白质结构进行高通量检测来定义人类疾病分子病理学的新方法，这将有助于生成一系列新的假设，通过对这些假设进行验证，能更好地理解该疾病并开发相应的治疗方法。
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Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.多发性硬化症患者血清和脑脊液中的髓鞘碱性蛋白反应性自身抗体具有低亲和力相互作用的特征。
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A controlled trial of natalizumab for relapsing multiple sclerosis.那他珠单抗治疗复发型多发性硬化症的对照试验。
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An array of sunshine in multiple sclerosis.多发性硬化症中的一系列阳光因素
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The structure of haplotype blocks in the human genome.人类基因组中单倍型块的结构。
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Haplotype tagging for the identification of common disease genes.用于识别常见疾病基因的单倍型标签
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High-resolution haplotype structure in the human genome.人类基因组中的高分辨率单倍型结构。
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