Yang Min, Li Ji-Xin, Li Xin, Jia Zhong-Jian
College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China.
Pharmazie. 2005 Jul;60(7):554-8.
From the methanol extract of the whole plant of Achillea wilsoniana, 23 compounds were isolated. Their structures were elucidated by spectroscopic methods and chemical transformations. Three of them are new: 4E, 10E-9beta-hydroxy-3-(2-methylbutyroyloxy)-germacra-4,10(1)-diene-12,6alpha-olide (1), 4E,10E-3-(2-methylbutyroyloxy)-germacra-4,10(1)-diene-12,6alpha-olide (2) and 1beta,6a-dihydroxy-10beta-methyl-5alphaH,7alphaH-eudesm-4-one (3). In addition, 1beta-hydroxy-alpha-xyperone (5) and 9beta-acetoxy-3-(2methylbutyroyloxy)-germacra-4,10(1)-diene-12,6alpha-olide (1a) exhibited effective antibacterial activity against Staphylococcus aureus.
从云南蓍全草的甲醇提取物中分离出23种化合物。通过光谱方法和化学转化对其结构进行了阐明。其中三种是新化合物：4E,10E-9β-羟基-3-(2-甲基丁酰氧基)-吉马-4,10(1)-二烯-12,6α-内酯(1)、4E,10E-3-(2-甲基丁酰氧基)-吉马-4,10(1)-二烯-12,6α-内酯(2)和1β,6a-二羟基-10β-甲基-5αH,7αH-桉叶-4-酮(3)。此外，1β-羟基-α-刺桉酮(5)和9β-乙酰氧基-3-(2-甲基丁酰氧基)-吉马-4,10(1)-二烯-12,6α-内酯(1a)对金黄色葡萄球菌表现出有效的抗菌活性。
