通过路易斯酸促进/铑催化的C-H键活化协同作用形成sp(3)-sp(3) C-C键的反应。
A reaction for sp(3)-sp(3) C-C bond formation via cooperation of Lewis acid-promoted/Rh-catalyzed C-H bond activation.
作者信息
Shi Lei, Tu Yong-Qiang, Wang Min, Zhang Fu-Min, Fan Chun-An, Zhao Yu-Ming, Xia Wu-Jiong
机构信息
State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
出版信息
J Am Chem Soc. 2005 Aug 10;127(31):10836-7. doi: 10.1021/ja0528331.
A new method for intermolecular sp3-sp3 C-C bond formation between primary aliphatic alcohol and olefin by use of a RhCl(PPh3)3 (cat.)/BF3.OEt2 (2.5 equiv)/BuBr (0.5 equiv)/toluene system was first disclosed, which possessed quite significant utilities for organic synthesis, especially for that of secondary alcohols. The most significant aspect is the discovery that rhodium-catalyzed C-H bond activation of alcohols is feasible under Lewis acid-promoted conditions.
首次公开了一种使用RhCl(PPh3)3（催化剂）/BF3·OEt2（2.5当量）/BuBr（0.5当量）/甲苯体系在伯脂肪醇和烯烃之间形成分子间sp3-sp3 C-C键的新方法，该方法在有机合成中具有相当重要的用途，特别是对于仲醇的合成。最显著的方面是发现铑催化的醇的C-H键活化在路易斯酸促进的条件下是可行的。
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