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银促进的醇的α-C-H芳基化反应。

The Ag-promoted α-C-H arylation of alcohols.

作者信息

Wang Shoufeng, Xing Shuya, Zhang Yingying, Fan Yafei, Zhao Huaiqing, Wang Jianfeng, Zhang Shuxiang, Wang Wengui

机构信息

School of Chemistry and Chemical Engineering, University of Jinan 336 West Road of Nan Xinzhuang Jinan 250022 China

Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials 336 West Road of Nan Xinzhuang Jinan 250022 China.

出版信息

RSC Adv. 2019 Dec 17;9(71):41847-41850. doi: 10.1039/c9ra09954a. eCollection 2019 Dec 13.

DOI:10.1039/c9ra09954a
PMID:35541603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9076519/
Abstract

We herein report the functionalization of α-C-H in alcohols through cross-dehydrogenative coupling reactions. Selectfluor was used as a mild oxidant. -generated HF participated in the reaction and no external strong acid was necessary. A variety of heteroaryl-substituted alcohols were achieved with good yields and with good functional group tolerance.

摘要

我们在此报道了通过交叉脱氢偶联反应实现醇类中α-C-H的官能团化。Selectfluor被用作温和的氧化剂。生成的HF参与反应，无需外加强酸。多种杂芳基取代的醇以良好的产率和良好的官能团耐受性得以实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/3f34b90269d9/c9ra09954a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/24330503b54c/c9ra09954a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/cfe192c48b17/c9ra09954a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/44fae81c4aac/c9ra09954a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/8bee33a0872b/c9ra09954a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/3f34b90269d9/c9ra09954a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/24330503b54c/c9ra09954a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/cfe192c48b17/c9ra09954a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/44fae81c4aac/c9ra09954a-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/8bee33a0872b/c9ra09954a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fa2/9076519/3f34b90269d9/c9ra09954a-s4.jpg

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Introduction of Quinolines and Isoquinolines onto Nonactivated α-C-H Bond of Tertiary Amides through a Radical Pathway.
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Free-Radical Triggered Ordered Domino Reaction: An Approach to C-C Bond Formation via Selective Functionalization of α-Hydroxyl-(sp(3))C-H in Fluorinated Alcohols.自由基引发的有序多米诺反应：通过氟化醇中 α-羟基-(sp(3))C-H 的选择性官能化构建 C-C 键。
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