Penchenier L, Alhadji D, Bahébégué S, Simo G, Laveissière C, Cuny G
Laboratoire de Recherches et de Coordination sur les Trypanosomes, UR035 (IRD) CIRAD, TA207/G, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France.
Vet Parasitol. 2005 Oct 10;133(1):7-11. doi: 10.1016/j.vetpar.2005.04.034.
The existence of a pig reservoir for human African trypanosomosis (HAT) due to Trypanosoma brucei gambiense complicates the fight against this disease. This study, reports results obtained from pigs, which were inoculated with the blood of a person, suffering from HAT in Cameroon. The pigs were reared and kept in the shelter from all contact with Glossina, and monitored for 188 days. The seroconversion was checked by agglutination assays for trypanosomosis (CATT 1.3 and LATEX/T.b.gambiense). The parasitemia was measured by quantitative buffy coat method (QBC) and by polymerase chain reaction method (PCR). In addition, growth was recorded as well as blood counting and blood formulas. The results showed that the pigs were trypanotolerant and cure themselves in less than 6 months. It is concluded that sterilisation of this reservoir could be achieved by tsetse-control measures in 1 year. It confirms the strategy to complement screening and treatment of HAT with tsetse fly control measures.
由布氏冈比亚锥虫引起的人类非洲锥虫病（昏睡病）存在猪宿主，这使对抗该疾病的斗争变得复杂。本研究报告了用喀麦隆一名昏睡病患者的血液接种猪后获得的结果。这些猪被饲养并安置在与采采蝇完全隔离的庇护所中，并监测了188天。通过锥虫病凝集试验（CATT 1.3和乳胶/布氏冈比亚锥虫）检查血清转化情况。通过定量血沉棕黄层法（QBC）和聚合酶链反应法（PCR）测量寄生虫血症。此外，记录生长情况以及血细胞计数和血液配方。结果表明，这些猪具有锥虫耐受性，并且在不到6个月的时间内自愈。得出的结论是，通过采采蝇控制措施可在1年内实现对该宿主的清除。这证实了用采采蝇控制措施补充昏睡病筛查和治疗的策略。
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