Matheus Maria E, Berrondo Luciane F, Vieitas Eniana C, Menezes Fábio S, Fernandes Patricia D
Departamento de Farmacologia, ICB, Universidade Federal do Rio de Janeiro, Brasil.
J Ethnopharmacol. 2005 Dec 1;102(3):377-81. doi: 10.1016/j.jep.2005.06.033. Epub 2005 Aug 1.
Brillantaisia palisotii Lindau is a plant belonging to Acanthaceae family and it is widely found in tropical regions. Some species of this family are used in the folk medicine to treat several disorders, mainly those that involve analgesic processes. In this work it was evaluated antinociceptive activities of dichloromethane, ethyl acetate and n-butanol extracts obtained from Brillantaisia palisotii stems in peripheral (acetic acid-induced writhing) and central (tail flick and hot plate) analgesic models. All three extracts significantly inhibited the total number of writhing in a dose dependent manner. A spinal antinociceptive effect was observed with all three extracts and with similar patterns to all doses (1-30 mg/kg). Although ethyl acetate extract did not demonstrate supra-spinal activity, the effects observed with dichloromethane extract showed analgesic effect with all doses. The n-butanolic extract had activity only with the lowest dose (1 mg/kg). Our results indicate that all extracts from Brillantaisia palisotti stems develop peripheral and spinal analgesic activity, being the dichloromethane extract the only one with supra-spinal analgesic effect.
林氏假尖蕊是一种属于爵床科的植物，广泛分布于热带地区。该科的一些物种在民间医学中用于治疗多种疾病，主要是那些涉及止痛过程的疾病。在这项研究中，评估了从林氏假尖蕊茎中获得的二氯甲烷、乙酸乙酯和正丁醇提取物在周围（乙酸诱导扭体）和中枢（甩尾和热板）镇痛模型中的抗伤害感受活性。所有三种提取物均以剂量依赖性方式显著抑制扭体总数。所有三种提取物均观察到脊髓抗伤害感受作用，且所有剂量（1-30mg/kg）的作用模式相似。虽然乙酸乙酯提取物未表现出脊髓上的活性，但二氯甲烷提取物在所有剂量下均显示出镇痛作用。正丁醇提取物仅在最低剂量（1mg/kg）时有活性。我们的结果表明，林氏假尖蕊茎的所有提取物均具有外周和脊髓镇痛活性，二氯甲烷提取物是唯一具有脊髓上镇痛作用的提取物。
