Morales Aixa V, Barbas Julio A, Nieto M Angela
Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain.
Semin Cell Dev Biol. 2005 Dec;16(6):655-62. doi: 10.1016/j.semcdb.2005.06.003. Epub 2005 Aug 1.
The development of the neural crest up to the stage where they leave the neural tube can be observed as a series of concatenated but independent events that involve dorsalization of the neural plate/neural tube, neural crest induction, segregation and stabilization, epithelial to mesenchymal transition and delamination. During all these processes, the nascent neural crest cells are subjected to the influence of different signals and have to overcome competition for cell fate and apoptotic signals. In addition, striking rostrocaudal differences unveil how the regulatory cascades are somehow different but still can lead to the production of bona fide neural crest cells.
在神经嵴离开神经管之前的发育过程，可以看作是一系列连续但独立的事件，包括神经板/神经管的背侧化、神经嵴诱导、分离与稳定、上皮到间充质转化和分层。在所有这些过程中，新生的神经嵴细胞受到不同信号的影响，并且必须克服细胞命运竞争和凋亡信号。此外，显著的头尾差异揭示了调控级联反应如何在某种程度上有所不同，但仍能导致真正的神经嵴细胞的产生。
