Beavers Kristen M, Nicklas Barbara J
J. Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest, University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Front Biosci (Schol Ed). 2011 Jan 1;3(1):168-77. doi: 10.2741/s142.
Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors which places individuals at increased risk for cardiovascular morbidity and mortality. In addition to obesity and insulin resistance, inflammation is emerging as a potential etiologic factor of the syndrome. One hypothesis suggests that obesity contributes to insulin resistance through increased production of adipose-derived inflammatory cytokines. Currently, lifestyle change is the first line of treatment for MetS. Only recently, however, have studies begun exploring the effect of lifestyle interventions on the mediation of inflammation in individuals with MetS. This review summarizes the strongest evidence (i.e. randomized controlled trial data) for a role of lifestyle interventions (diet and/or exercise) on the improvement of inflammatory biomarkers in people with MetS. Of six studies assessed, lifestyle interventions were consistently successful at improving the inflammatory and metabolic profiles. Interestingly, improvements in the inflammatory profile were found to be largely independent of obesity. Data currently suggest that alterations in dietary composition may be the most effective lifestyle change, although there is a need for more research in this area.
代谢综合征（MetS）是心血管危险因素的聚集，使个体患心血管疾病和死亡的风险增加。除肥胖和胰岛素抵抗外，炎症正成为该综合征的一个潜在病因。一种假说认为，肥胖通过增加脂肪源性炎症细胞因子的产生导致胰岛素抵抗。目前，生活方式改变是代谢综合征的一线治疗方法。然而，直到最近才有研究开始探索生活方式干预对代谢综合征患者炎症调节的影响。本综述总结了生活方式干预（饮食和/或运动）对改善代谢综合征患者炎症生物标志物作用的最有力证据（即随机对照试验数据）。在评估的六项研究中，生活方式干预在改善炎症和代谢状况方面一直很成功。有趣的是，发现炎症状况的改善在很大程度上与肥胖无关。目前的数据表明，饮食成分的改变可能是最有效的生活方式改变，尽管这一领域还需要更多的研究。
