Ikegami A, Kato J
Department of Obstetrics and Gynecology, Yamanashi Medical College.
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Mar;44(3):336-40.
To clarify the mechanism of the origin of adenomyosis, we investigated the immunohistochemical distribution of collagen type III in the human endometrium and the adenomyosis throughout the menstrual cycle. 1) Collagen type III was localized in the stroma of normal endometrium and ectopic endometrium, and in the myometrium. No staining of collagen type III was observed in the endometrial gland. 2) The intensity of staining for collagen type III in the basal layer of normal endometrium was stronger than those in the functional layer. The staining in the proliferative phase was stronger than that in the secretory phase. 3) The intensity of staining of collagen type III in ectopic endometrium paralleled that in the basal layer of normal endometrium. 4) The intensity of staining of collagen type III in the myometrium did not change throughout the menstrual cycle. These results suggest that close similarities exist between stromal cells in normal endometrium and in ectopic endometrium from the viewpoint of the extracellular matrix.
为阐明子宫腺肌病的起源机制，我们研究了Ⅲ型胶原蛋白在人子宫内膜及子宫腺肌病组织中整个月经周期的免疫组化分布情况。1）Ⅲ型胶原蛋白定位于正常子宫内膜和异位子宫内膜的间质以及子宫肌层。在子宫内膜腺体中未观察到Ⅲ型胶原蛋白染色。2）正常子宫内膜基底层Ⅲ型胶原蛋白的染色强度强于功能层。增殖期的染色强于分泌期。3）异位子宫内膜中Ⅲ型胶原蛋白的染色强度与正常子宫内膜基底层的相似。4）子宫肌层中Ⅲ型胶原蛋白的染色强度在整个月经周期中没有变化。这些结果表明，从细胞外基质的角度来看，正常子宫内膜和异位子宫内膜的间质细胞之间存在密切相似性。
