Koelsch Stefan, Fritz Thomas, V Cramon D Yves, Müller Karsten, Friederici Angela D
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Hum Brain Mapp. 2006 Mar;27(3):239-50. doi: 10.1002/hbm.20180.
The present study used pleasant and unpleasant music to evoke emotion and functional magnetic resonance imaging (fMRI) to determine neural correlates of emotion processing. Unpleasant (permanently dissonant) music contrasted with pleasant (consonant) music showed activations of amygdala, hippocampus, parahippocampal gyrus, and temporal poles. These structures have previously been implicated in the emotional processing of stimuli with (negative) emotional valence; the present data show that a cerebral network comprising these structures can be activated during the perception of auditory (musical) information. Pleasant (contrasted to unpleasant) music showed activations of the inferior frontal gyrus (IFG, inferior Brodmann's area (BA) 44, BA 45, and BA 46), the anterior superior insula, the ventral striatum, Heschl's gyrus, and the Rolandic operculum. IFG activations appear to reflect processes of music-syntactic analysis and working memory operations. Activations of Rolandic opercular areas possibly reflect the activation of mirror-function mechanisms during the perception of the pleasant tunes. Rolandic operculum, anterior superior insula, and ventral striatum may form a motor-related circuitry that serves the formation of (premotor) representations for vocal sound production during the perception of pleasant auditory information. In all of the mentioned structures, except the hippocampus, activations increased over time during the presentation of the musical stimuli, indicating that the effects of emotion processing have temporal dynamics; the temporal dynamics of emotion have so far mainly been neglected in the functional imaging literature.
本研究使用愉悦和不愉悦的音乐来诱发情绪，并采用功能磁共振成像（fMRI）来确定情绪加工的神经关联。与愉悦（和谐）音乐形成对比的不愉悦（持续不和谐）音乐，显示杏仁核、海马体、海马旁回和颞极激活。这些结构先前已被认为与具有（负性）情绪效价的刺激的情绪加工有关；目前的数据表明，在听觉（音乐）信息感知过程中，包含这些结构的脑网络能够被激活。愉悦（与不愉悦相对比）音乐显示额下回（IFG，布罗德曼区（BA）44区、45区和46区）、前上岛叶、腹侧纹状体、赫氏回和中央沟盖激活。IFG激活似乎反映音乐句法分析和工作记忆操作过程。中央沟盖区域的激活可能反映在愉悦曲调感知过程中镜像功能机制的激活。中央沟盖、前上岛叶和腹侧纹状体可能形成一个与运动相关的神经回路，在愉悦听觉信息感知过程中为发声产生（运动前）表征服务。在所有上述结构中，除了海马体，在音乐刺激呈现过程中激活随时间增加，表明情绪加工的效应具有时间动态性；情绪的时间动态性在功能成像文献中迄今主要被忽视。
