Mitterschiffthaler Martina T, Fu Cynthia H Y, Dalton Jeffrey A, Andrew Christopher M, Williams Steven C R
King's College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, United Kingdom.
Hum Brain Mapp. 2007 Nov;28(11):1150-62. doi: 10.1002/hbm.20337.
The present study investigated the functional neuroanatomy of transient mood changes in response to Western classical music. In a pilot experiment, 53 healthy volunteers (mean age: 32.0; SD = 9.6) evaluated their emotional responses to 60 classical musical pieces using a visual analogue scale (VAS) ranging from 0 (sad) through 50 (neutral) to 100 (happy). Twenty pieces were found to accurately induce the intended emotional states with good reliability, consisting of 5 happy, 5 sad, and 10 emotionally unevocative, neutral musical pieces. In a subsequent functional magnetic resonance imaging (fMRI) study, the blood oxygenation level dependent (BOLD) signal contrast was measured in response to the mood state induced by each musical stimulus in a separate group of 16 healthy participants (mean age: 29.5; SD = 5.5). Mood state ratings during scanning were made by a VAS, which confirmed the emotional valence of the selected stimuli. Increased BOLD signal contrast during presentation of happy music was found in the ventral and dorsal striatum, anterior cingulate, parahippocampal gyrus, and auditory association areas. With sad music, increased BOLD signal responses were noted in the hippocampus/amygdala and auditory association areas. Presentation of neutral music was associated with increased BOLD signal responses in the insula and auditory association areas. Our findings suggest that an emotion processing network in response to music integrates the ventral and dorsal striatum, areas involved in reward experience and movement; the anterior cingulate, which is important for targeting attention; and medial temporal areas, traditionally found in the appraisal and processing of emotions.
本研究调查了对西方古典音乐做出反应时短暂情绪变化的功能性神经解剖学。在一项初步实验中，53名健康志愿者（平均年龄：32.0岁；标准差=9.6）使用从0（悲伤）到50（中性）再到100（快乐）的视觉模拟量表（VAS）评估了他们对60首古典音乐作品的情绪反应。发现有20首作品能够可靠地准确诱发预期的情绪状态，其中包括5首快乐、5首悲伤以及10首情绪无唤起作用的中性音乐作品。在随后的功能磁共振成像（fMRI）研究中，在另一组16名健康参与者（平均年龄：29.5岁；标准差=5.5）中，测量了对每种音乐刺激诱发的情绪状态做出反应时的血氧水平依赖（BOLD）信号对比度。扫描期间的情绪状态评分通过VAS进行，这证实了所选刺激的情绪效价。在呈现快乐音乐时，腹侧和背侧纹状体、前扣带回、海马旁回和听觉联合区的BOLD信号对比度增加。对于悲伤音乐，海马体/杏仁核和听觉联合区的BOLD信号反应增加。呈现中性音乐与脑岛和听觉联合区的BOLD信号反应增加有关。我们的研究结果表明，对音乐做出反应的情绪处理网络整合了腹侧和背侧纹状体，这些区域参与奖励体验和运动；前扣带回，对注意力定向很重要；以及内侧颞叶区域，传统上这些区域参与情绪的评估和处理。
