特发性股骨头坏死中的关节生物标志物：与髋骨关节炎的比较

Joint biomarkers in idiopathic femoral head osteonecrosis: comparison with hip osteoarthritis.

作者信息

Kato Shinichi, Yamada Harumoto, Terada Nobuki, Masuda Koichi, Lenz Mary Ellen, Morita Mitsuhiro, Yoshihara Yasuo, Henmi Osamu

机构信息

Department of Orthopaedic Surgery, Fujita Health University, Second Hospital, Nagoya, Japan.

出版信息

J Rheumatol. 2005 Aug;32(8):1518-23.

PMID:16078329

Abstract

OBJECTIVE

To compare concentrations of joint biomarkers in synovial fluid (SF) between idiopathic osteonecrosis of the femoral head (ION) and osteoarthritis (OA) of the hip joint.

METHODS

Levels of the joint biomarkers cartilage oligomeric matrix protein (COMP), antigenic keratan sulfate (AgKS), and hyaluronan (HA) in SF samples from 21 cases of ION and their relationship to disease stage and history of steroid use were assessed and compared to the result of 29 cases of hip OA.

RESULTS

In both the ION and hip OA groups, levels of COMP and AgKS in SF showed a significant positive correlation. The ION group had significantly higher levels of AgKS in SF than the hip OA group. In the ION group, stage II patients had significantly higher SF levels of both COMP and AgKS than those in stage III patients. No difference in level of HA in hip joint SF was found between steroid and non-steroid treated ION patients or between the stage II and III subgroups.

CONCLUSION

SF levels of COMP and AgKS may serve as useful joint biomarkers that reflect cartilage metabolism not only in hip OA but also in ION.

摘要

目的

比较股骨头特发性骨坏死（ION）与髋关节骨关节炎（OA）患者滑液（SF）中关节生物标志物的浓度。

方法

评估21例ION患者SF样本中关节生物标志物软骨寡聚基质蛋白（COMP）、抗原性硫酸角质素（AgKS）和透明质酸（HA）的水平及其与疾病分期和类固醇使用史的关系，并与29例髋关节OA患者的结果进行比较。

结果

在ION组和髋关节OA组中，SF中COMP和AgKS的水平均呈显著正相关。ION组SF中AgKS的水平显著高于髋关节OA组。在ION组中，II期患者SF中COMP和AgKS的水平均显著高于III期患者。在接受类固醇治疗和未接受类固醇治疗的ION患者之间，以及II期和III期亚组之间，髋关节SF中HA水平无差异。