Haupt M, Kurz A, Pollmann S, Romero B
Psychiatrische Klinik, Technischen Universität, München, Federal Republic of Germany.
J Neurol. 1992 May;239(5):248-50. doi: 10.1007/BF00810345.
Ninety outpatients with Alzheimer's disease according to ICD-10 diagnostic draft criteria were studied to test the hypothesis that cases with a familial aggregation are different from cases without such an aggregation with respect to cognitive impairment. In all cases the diagnosis of Alzheimer's disease was confirmed by prospective observation within 12 months of initial evaluation. Patients were divided into two groups: one consisting of 23 patients with a familial aggregation, the other consisting of 67 patients without secondary cases among first-degree relatives. By means of t-tests differences in impairment of cognitive functions between the groups were calculated. The results did not yield statistically significant differences between the groups for any of the neuropsychologically investigated cognitive deficits. Thus the hypothesis that the presence of a familial aggregation may lead to a distinct phenotype in Alzheimer's disease was not confirmed.
根据国际疾病分类第10版（ICD - 10）诊断草案标准，对90名阿尔茨海默病门诊患者进行了研究，以检验以下假设：在认知障碍方面，有家族聚集性的病例与无家族聚集性的病例存在差异。在所有病例中，阿尔茨海默病的诊断通过初次评估后12个月内的前瞻性观察得以证实。患者被分为两组：一组由23名有家族聚集性的患者组成，另一组由67名在一级亲属中无二级病例的患者组成。通过t检验计算两组之间认知功能损害的差异。对于任何经神经心理学研究的认知缺陷，结果均未显示两组之间存在统计学上的显著差异。因此，家族聚集性的存在可能导致阿尔茨海默病出现独特表型这一假设未得到证实。
