Haupt M, Pollmann S, Kurz A
Psychiatric clinic, Technical University, Munich, Germany.
Acta Neurol Scand. 1993 Nov;88(5):349-53. doi: 10.1111/j.1600-0404.1993.tb05356.x.
We investigated the hypotheses that symptom progression in Alzheimer's disease is related to onset age and familial aggregation. In a psychiatric outpatient clinic we examined a cohort of 265 consecutively admitted patients 90 of which were diagnosed mild to moderate Alzheimer's disease according to the ICD-10 research criteria. Within twelve months follow-up 73 cases of these 90 patients were investigated twice. We found that early onset cases compared to late onset cases as well as patients with a familial aggregation compared to patients without such an aggregation were no different with respect to the rate of symptom progression in Alzheimer's disease. Furthermore, the hypothesis that early onset cases with a familial aggregation more rapidly deteriorate cognitively compared to late onset cases without such an aggregation could not be confirmed. Our results suggest that the large interindividual variation of symptom progression in Alzheimer's disease cannot be explained by onset age and familial aggregation.
阿尔茨海默病的症状进展与发病年龄和家族聚集性有关。在一家精神科门诊诊所，我们检查了连续收治的265名患者，其中90名根据ICD - 10研究标准被诊断为轻度至中度阿尔茨海默病。在12个月的随访期内，对这90名患者中的73例进行了两次调查。我们发现，早发型病例与晚发型病例相比，以及有家族聚集性的患者与无家族聚集性的患者相比，在阿尔茨海默病症状进展速度方面并无差异。此外，与无家族聚集性的晚发型病例相比，有家族聚集性的早发型病例认知功能衰退更快这一假设也未得到证实。我们的结果表明，阿尔茨海默病症状进展的个体间巨大差异无法用发病年龄和家族聚集性来解释。
