线虫 Cunninghamella elegans 对炔雌醇的微生物转化
Microbial transformation of mestranol by Cunninghamella elegans.
作者信息
Choudhary Muhammad Iqbal, Musharraf Syed Ghulam, Siddiqui Zafar Ali, Khan Naik Tameen, Ali Rahat Azhar, Ur-Rahman Atta
机构信息
International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
出版信息
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1011-3. doi: 10.1248/cpb.53.1011.
The microbial transformation of an oral contraceptive, mestranol (1) by Cunninghamella elegans yielded two hydroxylated metabolites, 6beta-hydroxymestranol (2) and 6beta,12beta-dihydroxymestranol (3). Metabolite 3 was found to be a new compound. These metabolites were structurally characterized on the basis of spectroscopic techniques.
用雅致小克银汉霉对口服避孕药炔雌醇甲醚（1）进行微生物转化，得到两种羟基化代谢产物，6β - 羟基炔雌醇甲醚（2）和6β,12β - 二羟基炔雌醇甲醚（3）。发现代谢产物3是一种新化合物。基于光谱技术对这些代谢产物进行了结构表征。
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