Kamochi Yasuko, Kudo Tadahiro, Masuda Toshinobu, Takadate Akira
Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan.
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1017-20. doi: 10.1248/cpb.53.1017.
The reduction of alpha- and beta-dicarbonyl compounds was investigated with samarium diiodide in the presence of additive. Diketones and ketocarboxylic acids were easily reduced at room temperature to give the mono-alcohols in good to excellent yield, and ketoester afforded the saturated ester as the major product in moderate yield. These reductions containing the reductive deoxygenation can be rapidly performed under the facile and mild conditions by this method.
在添加剂存在的情况下，用二碘化钐研究了α-和β-二羰基化合物的还原反应。二酮和酮羧酸在室温下很容易被还原，以良好至优异的产率得到单醇，酮酯以中等产率得到饱和酯作为主要产物。通过这种方法，这些包含还原性脱氧的还原反应可以在简便温和的条件下快速进行。
