Swaroop Anand, Sinha Arun Kumar, Chawla Raman, Arora Rajesh, Sharma Rakesh Kumar, Kumar Jonala Kotesh
Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur, H.P.-176061, India.
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1021-4. doi: 10.1248/cpb.53.1021.
1,3-Dicapryloyl-2-linoleoylglycerol (1), a novel triglyceride, was isolated from berries of Hippophae rhamnoides. The structure was elucidated on the basis of MS, 1D and 2D NMR experiments including HMQC and HMBC. The metal chelating, free radical scavenging, and lipid peroxidation inhibiting properties of the compound were also estimated with particular reference to radiation protection. In case of metal chelation and superoxide ion scavenging, 1 showed maximum inhibition at 50 microg/ml (11%) and 100 microg/ml (55%), respectively, whereas in lipid peroxidation, 1 showed maximum inhibition (57%) at 2 mg/ml as compared to quercetin as a control.
1,3-二辛酰基-2-亚油酰基甘油（1）是一种新型甘油三酯，从沙棘果实中分离得到。通过质谱、一维和二维核磁共振实验（包括HMQC和HMBC）对其结构进行了鉴定。还特别参照辐射防护对该化合物的金属螯合、自由基清除和脂质过氧化抑制特性进行了评估。在金属螯合和超氧阴离子清除方面，化合物1分别在50微克/毫升（11%）和100微克/毫升（55%）时表现出最大抑制作用，而在脂质过氧化方面，与作为对照的槲皮素相比，化合物1在2毫克/毫升时表现出最大抑制作用（57%）。
