Cooke Gerald L, Chien Anna, Brodsky Amy, Lee Raphael C
Department of Surgery, Medicine and Organismal Biology & Anatomy, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA.
J Natl Med Assoc. 2005 Jul;97(7):1004-9.
The pathogenesis and progression of wound-healing involve intricate pathways and numerous chemical mediators. This remains an area of intense study as undesirable results of this process, such as hypertrophic scars and keloids, can result in significant morbidity. These lesions are distinct in their characteristics, although they are similar in their distribution in patients with darker skin colors. There is a robust inflammatory mechanism behind the formation of hypertrophic scars and keloids. Furthermore, their development may be intimately related to vitamin D-3, which has been shown to be a powerful anti-inflammatory agent. This chemical is made in the skin, whose production is influenced by various factors of which the amount of melanin is a crucial one. More specifically, an increase in pigmentation has been shown to decrease the amount of vitamin D-3 synthesis in the skin. Thus, this paper proposes the hypothesis linking the propensity of inflammation and subsequent scarring in darker-skinned individuals to the reduced levels of vitamin D-3 production in their skin.
伤口愈合的发病机制和进展涉及复杂的途径和众多化学介质。这仍是一个深入研究的领域，因为这一过程的不良结果，如增生性瘢痕和瘢痕疙瘩，会导致显著的发病率。这些病变在特征上有所不同，尽管它们在肤色较深的患者中的分布相似。增生性瘢痕和瘢痕疙瘩的形成背后存在强大的炎症机制。此外，它们的发展可能与维生素D-3密切相关，维生素D-3已被证明是一种强大的抗炎剂。这种化学物质在皮肤中产生，其生成受多种因素影响，其中黑色素的量是关键因素之一。更具体地说，色素沉着增加已被证明会减少皮肤中维生素D-3的合成量。因此，本文提出了一个假说，将肤色较深个体的炎症倾向及随后的瘢痕形成与他们皮肤中维生素D-3生成水平降低联系起来。
