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曲安奈德玻璃体内注射治疗合并脉络膜脱离的视网膜脱离的初步研究

[The pilot study of intravitreal injection of triamcinolone acetonide for treatment of retinal detachment with choroidal detachment].

作者信息

Duan An-li, Wang Jing-zhao, Wang Ning-li

机构信息

Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences, Beijing 100730, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2005 Jul;41(7):606-9.

Abstract

OBJECTIVE

To evaluate the efficiency and safety of intravitreal injection of triamcinolone acetonide for treatment of retinal detachment with choroidal detachment.

METHODS

13 the patients (13 eyes) of retinal detachment with choroidal detachment were chosen and triamcinolone acetonide 0.1 ml (4 mg) were administrated via intravitreal injection through pars plana. The therapeutic effects on uveitis and choroidal detachment was analyzed. The retinal reattachment surgery was performed five to ten days after the injection.

RESULTS

all 13 patients receiving triamcinolone acetonide demonstrated alleviated uveitis to some degree. The rate of retinal holes detection increased from 2/13 pre-injection to 7/13 post-operation. Choroidal detachment disappeared in most of cases within 10 days triamcinolone acetonide injection. Five eyes underwent scleral buckling, 6 eyes underwent with vitrectomy, and 2 patients abandoned surgery. The average follow up after surgery was 4 and half months. All eyes received with triamcinolone acetonide injection and surgery had retinal reattached successfully and no side effects were detected.

CONCLUSIONS

Intravitreal injection of triamcinolone acetonide was an effective and safe method to treat choroidal detachment and alleviate uveitis. The injection simplified surgery procedure and improve the success rate of retinal detachment.

摘要

目的

评估玻璃体内注射曲安奈德治疗视网膜脱离合并脉络膜脱离的有效性和安全性。

方法

选取13例视网膜脱离合并脉络膜脱离患者(13只眼),经睫状体平坦部行玻璃体内注射曲安奈德0.1 ml(4 mg),分析其对葡萄膜炎和脉络膜脱离的治疗效果。注射后5至10天进行视网膜复位手术。

结果

13例接受曲安奈德注射的患者葡萄膜炎均有不同程度缓解。术前视网膜裂孔检出率为2/13,术后为7/13。多数患者在注射曲安奈德后10天内脉络膜脱离消失。5只眼行巩膜扣带术,6只眼行玻璃体切除术,2例患者放弃手术。术后平均随访4个半月。所有接受曲安奈德注射及手术的患眼视网膜均成功复位,未发现副作用。

结论

玻璃体内注射曲安奈德是治疗脉络膜脱离和缓解葡萄膜炎的有效、安全方法。该注射方法简化了手术操作,提高了视网膜脱离手术成功率。

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