伴8号染色体四体的急性髓系白血病是一种预后较差的疾病。

Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis.

作者信息

Tsirigotis Panagiotis, Papageorgiou Sotirios, Abatzis Danai, Athanatou Sofia, Girkas Constantinos, Pappa Vasiliki, Pangalos Constantinos, Papageorgiou Efstathios, Dervenoulas John, Raptis Sotirios

机构信息

Second Department of Internal Medicine, Propaedeutic, Haematology Unit, University of Athens, Attikon Hospital, 1 Rimini Street, Haidari 124 62, Greece.

出版信息

Cancer Genet Cytogenet. 2005 Aug;161(1):78-81. doi: 10.1016/j.cancergencyto.2004.12.016.

DOI:10.1016/j.cancergencyto.2004.12.016

PMID:16080962

Abstract

Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies. The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage. In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality. Fluorescence in situ hybridization revealed tetrasomy 8 and trisomy 8 concurrently in all but one of the bone marrow samples. The clonal relationship between trisomy 8 and tetrasomy 8 in these cases remains to be clarified. Patients with tetrasomy 8 have a poor prognosis, and only 1 out of 33 patients was free of disease 3 years after autologous bone marrow transplantation. Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8.

摘要

8号染色体四体异常是一种极其罕见的染色体异常，仅在少数髓系恶性肿瘤病例中有报道。大多数报道的病例为单核细胞系急性髓系白血病（AML）。略多于半数的患者中，8号染色体四体是唯一的细胞遗传学异常。荧光原位杂交显示，除一份骨髓样本外，所有样本均同时存在8号染色体四体和三体。这些病例中8号染色体三体和四体之间的克隆关系仍有待阐明。8号染色体四体的患者预后较差，33例患者中只有1例在自体骨髓移植后3年无疾病。在此，我们报告一例患有单核细胞白血病和8号染色体四体的25岁女性患者。