Miyagawa A, Taniguchi K, Sendaya K, Mizutani A, Yoshitake S, Ikebe H, Honda N
Department of Anesthesiology, Medical College of Oita.
Masui. 1992 May;41(5):805-10.
We studied usefulness of iontophoresis on pain relief using several Ca channel blockers, propranolol and guanethidine. Subjects were 18 healthy adult volunteers. We used 4% lidocaine with/without several drugs (2 mg of nicardipine, verapamil, diltiazem, propranolol and 10mg of guanethidine), and evaluated the pain relief effect with Nakahama's algesimeter. In all groups except for propranolol group, the pain recognition time was elongated significantly in comparison with control. In making comparison between each Ca channel blocker, we did not observe any significant differences, but, in propranolol group, elongation of pain threshold time was observed in some subjects. During these processes, systemic blood pressure and heart rate showed no remarkable changes. Our results suggest that it is possible to achieve more prolonged analgesic effect by the Ca channel blockers.
我们使用几种钙通道阻滞剂、普萘洛尔和胍乙啶研究了离子电渗疗法对缓解疼痛的有效性。研究对象为18名健康成年志愿者。我们使用含/不含几种药物（2毫克尼卡地平、维拉帕米、地尔硫卓、普萘洛尔和10毫克胍乙啶）的4%利多卡因，并使用中浜痛觉计评估止痛效果。除普萘洛尔组外，所有组的疼痛识别时间与对照组相比均显著延长。在比较每种钙通道阻滞剂时，我们未观察到任何显著差异，但在普萘洛尔组中，一些受试者的疼痛阈值时间延长。在这些过程中，全身血压和心率未出现明显变化。我们的结果表明，钙通道阻滞剂有可能实现更持久的镇痛效果。
