Taniguchi K, Miyagawa A, Mizutani A, Honda N, Oyama T
Department of Anesthesiology, Oita Medical University, Japan.
Acta Anaesthesiol Belg. 1995;46(2):69-73.
Three calcium (Ca) channel antagonists were administered to healthy adult volunteers by iontophoresis alone or in combination with lidocaine to study their effects on the pain threshold. Nicardipine, verapamil or diltiazem administered alone elevated the pain threshold to the same degree as lidocaine. When Ca channel antagonists were administered in combination with lidocaine, the pain threshold elevation was not changed, but the duration of the analgesic action was prolonged when compared with lidocaine alone. These results suggest a role of the calcium channel in the pain control mechanism and the possible clinical application of Ca channel antagonists delivered by iontophoresis in pain management.
单独或与利多卡因联合通过离子导入法对健康成年志愿者施用三种钙（Ca）通道拮抗剂，以研究它们对痛阈的影响。单独施用尼卡地平、维拉帕米或地尔硫卓使痛阈升高至与利多卡因相同的程度。当钙通道拮抗剂与利多卡因联合施用时，痛阈升高没有变化，但与单独使用利多卡因相比，镇痛作用的持续时间延长。这些结果提示钙通道在疼痛控制机制中的作用以及离子导入法递送的钙通道拮抗剂在疼痛管理中的可能临床应用。
