Mizutani A, Taniguchi K, Miyagawa A, Ikebe H, Yoshitake S, Honda N
Department of Anesthesiology, Medical College of Oita.
Masui. 1993 May;42(5):698-702.
We investigated calcium ion effects on pain thresholds by iontophoresis in healthy adult volunteers. The pain thresholds were measured by the pain thermometer to evaluate the effect of iontophoresis. At first, one of calcium channel blockers (nicardipine, verapamil or diltiazem) was administered by iontophoresis with 1.0 mA for 10 minutes. Then, next to calcium channel blockers, calcium chloride or saline was locally administered after the elevation of pain threshold had been recognized and the pain threshold had been measured again. Calcium ion decreased the elevation of pain threshold significantly, but saline had no effect. These results suggest that not only sodium channel but also calcium channel influences pain mechanism during iontophoresis.
我们通过离子导入法研究了钙离子对健康成年志愿者疼痛阈值的影响。使用疼痛温度计测量疼痛阈值以评估离子导入的效果。首先，通过离子导入法以1.0毫安的电流持续10分钟给予一种钙通道阻滞剂（尼卡地平、维拉帕米或地尔硫䓬）。然后，在确认疼痛阈值升高并再次测量疼痛阈值后，在钙通道阻滞剂旁边局部给予氯化钙或生理盐水。钙离子显著降低了疼痛阈值的升高，但生理盐水没有效果。这些结果表明，在离子导入过程中，不仅钠通道而且钙通道都影响疼痛机制。
