Ivanov K S, Murashov B F, Kapustin V M
Klin Med (Mosk). 1992 Jan;70(1):70-3.
Metabolites of connective tissue (free serum oxyproline, protein-bound plasma oxyproline, total urine oxyproline, serum glycosaminoglycans), proteolytic enzyme elastase, proteolysis inhibitors (alpha 1-inhibitor, alpha 2-macroglobulin) were investigated in 103 patients with viral hepatitis A. It was established that connective tissue and its metabolites produce a negative effect on hepatocytic repair. Longterm convalescence is attributed to elastase hyperactivity in the presence of relative deficiency of proteolytic inhibitors.
对103例甲型病毒性肝炎患者的结缔组织代谢产物（游离血清羟脯氨酸、蛋白结合血浆羟脯氨酸、总尿羟脯氨酸、血清糖胺聚糖）、蛋白水解酶弹性蛋白酶、蛋白水解抑制剂（α1-抑制剂、α2-巨球蛋白）进行了研究。结果表明，结缔组织及其代谢产物对肝细胞修复产生负面影响。长期康复归因于蛋白水解抑制剂相对缺乏时弹性蛋白酶的活性过高。
