[慢性肝病患者胶原代谢的各种特征]

[Various characteristics of collagen metabolism in patients with chronic diseases of the liver].

作者信息

Geĭvandova N I, Iagoda A V, Mosin V I

出版信息

Klin Med (Mosk). 1989 Nov;67(11):59-62.

Abstract

The correlation of collagen metabolism to liver contents of cyclic AMP and GMP as well as blood level of hormones was investigated in 105 patients with chronic hepatitis and liver cirrhosis. In patients with active hepatitis and cirrhosis showing the highest intensity of collagen metabolism there appeared elevated levels of cyclic AMP, somatotropic hormone and insulin against low levels of hydrocortisone and thyroxin. The relations between characteristics of plasma protein-bound oxyproline (PBOP), circadian oxyprolinuria and regulatory mechanisms under study suggest a competitive control of hepatic connective tissue metabolism maintained by hormones via cyclase systems. In high levels of blood PBOP and low ones of hydrocortisone, glucocorticoids unlike D-penicillamine promoted inhibition of liver collagen synthesis.

摘要

对105例慢性肝炎和肝硬化患者，研究了胶原代谢与肝脏中环磷酸腺苷（cAMP）和环磷酸鸟苷（GMP）含量以及血液中激素水平的相关性。在胶原代谢强度最高的活动性肝炎和肝硬化患者中，出现了cAMP、生长激素和胰岛素水平升高，而氢化可的松和甲状腺素水平降低。血浆蛋白结合羟脯氨酸（PBOP）特征、昼夜尿羟脯氨酸排泄量与所研究的调节机制之间的关系表明，激素通过环化酶系统对肝脏结缔组织代谢进行竞争性控制。在血液PBOP水平高而氢化可的松水平低时，与青霉胺不同，糖皮质激素可促进肝脏胶原合成的抑制。