Rezk Sherif, Khan Ashraf
Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, Massachusetts 01655, USA.
Appl Immunohistochem Mol Morphol. 2005 Sep;13(3):256-64. doi: 10.1097/01.pai.0000142823.56602.fe.
Thyroid carcinoma derived from the thyroid hormone-producing follicular epithelium is the most common thyroid malignancy. While the morphologic diagnosis of conventional papillary thyroid carcinoma is simple, thyroid tumors with a follicular pattern are sometimes a diagnostic challenge. It is in the latter group of thyroid neoplasms that ancillary diagnostic tests such as immunohistochemistry may be of great help. Furthermore, while most differentiated thyroid carcinomas have an excellent prognosis, a subset of these tumors may progress to a poorly or undifferentiated phenotype indicating an aggressive biologic behavior that may lead to systemic spread and death. Application of immunohistochemistry to identify a subset of thyroid carcinoma that may progress to a biologically aggressive phenotype may help in the management of patients with thyroid carcinoma. This review discusses the role of immunohistochemistry in the diagnosis and progression of thyroid carcinoma is discussed.
源自产生甲状腺激素的滤泡上皮的甲状腺癌是最常见的甲状腺恶性肿瘤。虽然传统乳头状甲状腺癌的形态学诊断很简单，但具有滤泡样形态的甲状腺肿瘤有时在诊断上具有挑战性。在后者这组甲状腺肿瘤中，免疫组织化学等辅助诊断测试可能会有很大帮助。此外，虽然大多数分化型甲状腺癌预后良好，但这些肿瘤中的一部分可能进展为低分化或未分化表型，表明其具有侵袭性生物学行为，可能导致全身扩散和死亡。应用免疫组织化学来识别可能进展为具有生物学侵袭性表型的甲状腺癌子集，可能有助于甲状腺癌患者的管理。本文综述了免疫组织化学在甲状腺癌诊断和进展中的作用。
