Perruccio Anthony V, Power J Denise, Badley Elizabeth M
University of Toronto, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.
Arthritis Rheum. 2005 Aug 15;53(4):571-7. doi: 10.1002/art.21317.
To longitudinally explore the hypothesized role of worsening pain and development of activity limitations as mediators in the relationship between arthritis onset and worsening self-rated health (SRH).
Data was obtained from the 1998/1999 and 2000/2001 cycles of the population-based Canadian longitudinal National Population Health Survey (n = 10,859; ages > or = 18; response rate: time 1 = 81.6%, time 2 = 89.2%). Respondents were asked about chronic conditions, pain, activity limitations, and self-perceived health; change over time was assessed. Change in effect of arthritis onset on worsening SRH upon considering potential mediators was assessed through multivariate logistic regression, controlling for sociodemographic characteristics and onset of other conditions.
Worsening pain fully explained the effect of arthritis onset on worsening SRH; a portion of the effect of worsening pain was mediated by the development of activity limitation. Residual direct effect of arthritis onset was statistically insignificant. Worsening pain and development of activity limitations also mediated a portion of the effects of onset of other chronic conditions but to a lesser extent than arthritis onset.
This is the first study to examine these relationships longitudinally. Identifying the role of mediators is necessary if target areas of prevention and/or management are sought, either at the individual or population level. Our results indicate that the development of arthritis has a significant impact on worsening SRH. Pain and development of activity limitations fully account for the relationship between arthritis onset and worsening SRH. High priority should be placed on prevention and management strategies for pain among people with arthritis.
纵向探究疼痛加剧和活动受限的发展作为关节炎发病与自评健康状况(SRH)恶化之间关系的中介因素的假设作用。
数据来源于基于人群的加拿大纵向国民健康调查的1998/1999年和2000/2001年两轮调查(n = 10,859;年龄≥18岁;回复率:第一次为81.6%,第二次为89.2%)。受访者被问及慢性病、疼痛、活动受限和自我感知健康状况;评估随时间的变化。通过多变量逻辑回归评估在考虑潜在中介因素后关节炎发病对SRH恶化的影响变化,并控制社会人口学特征和其他疾病的发病情况。
疼痛加剧完全解释了关节炎发病对SRH恶化的影响;疼痛加剧的部分影响由活动受限的发展介导。关节炎发病的残余直接效应在统计学上不显著。疼痛加剧和活动受限的发展也介导了其他慢性病发病的部分影响,但程度小于关节炎发病。
这是第一项纵向研究这些关系的研究。如果要在个体或人群层面寻找预防和/或管理的目标领域,确定中介因素的作用是必要的。我们的结果表明,关节炎的发展对SRH恶化有显著影响。疼痛和活动受限的发展完全解释了关节炎发病与SRH恶化之间的关系。应高度重视针对关节炎患者疼痛的预防和管理策略。