[奥沙美辛和舒林酸对前列腺素合成的影响]

[Effect of oxamethacin and sulindac on prostaglandin synthesis].

Damas J, Volon G

C R Seances Soc Biol Fil. 1979;173(4):849-53.

Abstract

Indomethacin and oxamethacin reduce the formation of malonaldehyde from arachidonic acid by rat platelets in vitro. Sulindac has no influence on this formation. 2. Indomethacin, oxamethacin and sulindac inhibit the action of arachidonic acid on the rat stomach strips in vitro. 3. These three anti-inflammatory drugs suppress the hypotensive activity of arachidonic acid in the rat in vivo. 4. The comparison of the inhibitory activities of these drugs in vivo and in vitro shows that sulindac is converted to a potent anti-prostaglandin-synthetase metabolite and that a part of the action of oxamethacin depends on its conversion to indomethacin in the rat.

摘要

吲哚美辛和奥沙美辛在体外可减少大鼠血小板由花生四烯酸生成丙二醛。舒林酸对此生成无影响。2. 吲哚美辛、奥沙美辛和舒林酸在体外可抑制花生四烯酸对大鼠胃条的作用。3. 这三种抗炎药在体内可抑制花生四烯酸对大鼠的降压活性。4. 这些药物在体内和体外抑制活性的比较表明，舒林酸可转化为一种强效的抗前列腺素合成酶代谢产物，且奥沙美辛的部分作用取决于其在大鼠体内转化为吲哚美辛。