Akkasilpa Somchai, Avihingsanon Yingyos, Hanvivadhanakul Punchong, Wonchinsri Jeerapat
Division of Rheumatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
J Med Assoc Thai. 2004 Sep;87 Suppl 2:S41-4.
To study the clinical manifestations of patients with hyperuricemia in King Chulalongkorn Memorial Hospital.
A cross sectional study of 188 hyperuricemic patients was done at King Chulalongkorn Memorial Hospital. History, physical examination, and blood samples were drawn to assess complete blood count (CBC), blood urea nitrogen (BUN), creatinine (Cr), liver function test (LFT), and serum uric acid in all patients.
Most of the patients (92%) were male, more than 50 years old (69%), the mean age of the patients was 56.7 +/- 12.1 years old. All of the female patients were more than 50 years old. Symptomatic hyperuricemia was found in 93%, the mean duration of symptoms was 63.2 +/- 66.3 months. The mean of the serum uric acid level was 10.0 +/- 2.9 mg/dl. Associated diseases were found in 46% of the patients, and 30% of these patients had more than one disease. Hypertension was the most common followed infrequency by dyslipidemia, diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease consecutively. Renal impairment was detected in about one-third of the patients.
This study shows that hyperuricemia is common in elderly, male patients. Associated diseases and renal impairment can befoundfrequently, and the patients should be monitored.
研究朱拉隆功纪念医院高尿酸血症患者的临床表现。
在朱拉隆功纪念医院对188例高尿酸血症患者进行了横断面研究。采集所有患者的病史、进行体格检查并抽取血样，以评估全血细胞计数（CBC）、血尿素氮（BUN）、肌酐（Cr）、肝功能测试（LFT）和血清尿酸。
大多数患者（92%）为男性，年龄超过50岁（69%），患者的平均年龄为56.7±12.1岁。所有女性患者年龄均超过50岁。93%的患者有症状性高尿酸血症，症状的平均持续时间为63.2±66.3个月。血清尿酸水平的平均值为10.0±2.9mg/dl。46%的患者有相关疾病，其中30%的患者患有不止一种疾病。高血压最为常见，其次依次为血脂异常、糖尿病、缺血性心脏病和慢性阻塞性肺疾病。约三分之一的患者检测出肾功能损害。
本研究表明，高尿酸血症在老年男性患者中很常见。经常会发现相关疾病和肾功能损害，应对患者进行监测。
