Veeravigrom Montida, Theamboonlers Apiradee, Poovorawan Yong
Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2004 Sep;87 Suppl 2:S50-4.
Acute gastroenteritis is one of the most common diseases affecting children and rotavirus is the major etiological agent worldwide. Although the role of rotavirus as a causal agent of gastroenteritis has been previously established in Thailand, little is known about the epidemiology of Norwalk-like viruses. The present study was designed to determine the epidemiology and clinical manifestation of Norwalk-like viruses in comparison with rotavirus in Thailand. One hundred and one children with watery diarrhea between November 2002 and October 2003 were recruited into the study. The clinical data and stool specimens were collected for clinical analysis and rotavirus and Norwalk-like virus detection. Rotavirus and Norwalk-like viruses were detected viral agent by RT-PCR method. Of 101 stool samples obtained, rotavirus was detected in 25/101 (24.7%). Norwalk-like viruses were detected in 23/101 (22.7%). Dual infections were detected in 6/101 (5.9%). Rotavirus and Norwalk-like viruses peaked in the winter time. Clinical manifestations of rotavirus and Norwalk-like viruses were watery stool, nausea, vomiting, abdominal pain and fever Norwalk-like viruses and rotavirus were the most common etiologic agents in children with acute gastroenteritis in Thailand Epidemiology and clinical manifestations of rotavirus and Norwalk-like viruses were not different.
急性胃肠炎是影响儿童的最常见疾病之一，轮状病毒是全球主要的病原体。尽管轮状病毒作为胃肠炎病原体的作用先前已在泰国得到证实，但对于诺如病毒样病毒的流行病学知之甚少。本研究旨在确定泰国诺如病毒样病毒与轮状病毒相比的流行病学和临床表现。2002年11月至2003年10月期间，101名患有水样腹泻的儿童被纳入研究。收集临床数据和粪便标本进行临床分析以及轮状病毒和诺如病毒样病毒检测。通过RT-PCR方法检测轮状病毒和诺如病毒样病毒病原体。在获得的101份粪便样本中，25/101（24.7%）检测到轮状病毒。23/101（22.7%）检测到诺如病毒样病毒。6/101（5.9%）检测到双重感染。轮状病毒和诺如病毒样病毒在冬季达到高峰。轮状病毒和诺如病毒样病毒的临床表现为水样便、恶心、呕吐、腹痛和发热。诺如病毒样病毒和轮状病毒是泰国急性胃肠炎儿童中最常见的病原体。轮状病毒和诺如病毒样病毒的流行病学和临床表现没有差异。
