Athyros Vasilios G, Ganotakis Emmanuel S, Elisaf Moses, Mikhailidis Dimitri P
Atherosclerosis and Metabolic Syndrome Units, 2nd Prop. Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece.
Curr Med Res Opin. 2005 Aug;21(8):1157-9. doi: 10.1185/030079905x53333.
The prevalence of metabolic syndrome (MetS), using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) definitions, was compared in 9669 subjects, representing the Greek population.
The age-adjusted prevalence of NCEP ATP III-defined MetS was 24.5% whereas that of IDF-defined MetS was 43.4% (+77%,p < 0.0001). The majority (up to 69%) of older age groups had IDF-defined MetS. The calculated vascular event risk was low (6.1% and 7.2% using the Framingham and PROCAM calculation, respectively) in those with IDF-defined MetS when compared with those with NCEP ATP III MetS (11.3% and 13.7%, respectively) (p < 0.0001 for both comparisons).
MetS could be considered as a 'normal' variant if it was present in the majority of the population. Moreover, the vascular risk associated with IDF-defined MetS could be low, raising cost-effectiveness issues. Alternatively, the new IDF definition may realistically reflect the current MetS epidemic. More studies are required to support or refute those interpretations.
采用美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP ATP III）和国际糖尿病联盟（IDF）的定义，对代表希腊人群的9669名受试者的代谢综合征（MetS）患病率进行比较。
经年龄调整后，NCEP ATP III定义的MetS患病率为24.5%，而IDF定义的MetS患病率为43.4%（增加77%，p<0.0001）。大多数老年组（高达69%）患有IDF定义的MetS。与患有NCEP ATP III定义的MetS的人群相比，患有IDF定义的MetS的人群计算出的血管事件风险较低（分别使用弗明汉姆和PROCAM计算方法，风险为6.1%和7.2%）（分别为11.3%和13.7%）（两项比较p均<0.0001）。
如果MetS存在于大多数人群中，可将其视为一种“正常”变异。此外，与IDF定义的MetS相关的血管风险可能较低，这就引发了成本效益问题。或者，新的IDF定义可能切实反映了当前的MetS流行情况。需要更多研究来支持或反驳这些解释。
