复发缓解型多发性硬化症患者血清中脑源性神经营养因子水平较低：醋酸格拉替雷可使其逆转。
Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate.
作者信息
Azoulay David, Vachapova Veronika, Shihman Boris, Miler Ariel, Karni Arnon
机构信息
Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
出版信息
J Neuroimmunol. 2005 Oct;167(1-2):215-8. doi: 10.1016/j.jneuroim.2005.07.001.
Neuronal growth factors may exert a neuroprotective effect in multiple sclerosis (MS). We found reduced levels of brain-derived neurotrophic factors (BDNF) in the serum and CSF of relapsing-remitting MS patients, which was reversed by therapy with glatiramer acetate. BDNF may play a protective role in MS, and immunomodulation therapy, such as with glatiramer acetate, may enhance the action this mechanism.
神经元生长因子可能在多发性硬化症（MS）中发挥神经保护作用。我们发现复发缓解型MS患者血清和脑脊液中脑源性神经营养因子（BDNF）水平降低，而醋酸格拉替雷治疗可使其逆转。BDNF可能在MS中发挥保护作用，免疫调节治疗，如使用醋酸格拉替雷，可能会增强这一机制的作用。
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