Huo Lei, Lai Syeling, Gladish Gregory, Czerniak Bogdan A, Moran Cesar A
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA.
Ann Diagn Pathol. 2005 Aug;9(4):209-14. doi: 10.1016/j.anndiagpath.2005.04.012.
A 69-year-old man presented with cough, shortness of breath, and fatigue. He was initially treated for allergies and then for pulmonary embolism. Radiologically, a tumor mass was found to occlude the right pulmonary artery and involve the pulmonary trunk. A right pneumonectomy was performed. Histologically, a cellular malignant spindle and epithelioid tumor with areas of necrosis and brisk mitotic activity was seen. In some areas, the tumor appeared to form vascular channels. Focal osteosarcomatous differentiation was present. Immunohistochemical studies were performed including vimentin, smooth muscle actin, desmin, CD31, CD34, S100, and pan-cytokeratin. The tumor cells were positive for CD31 and vimentin and negative for pan-cytokeratin, CD34, and S100. Two months after surgery, the patient was alive and well.
一名69岁男性出现咳嗽、气短和乏力症状。他最初接受了过敏治疗，随后又接受了肺栓塞治疗。影像学检查发现一个肿瘤肿块阻塞了右肺动脉并累及肺动脉主干。遂行右肺切除术。组织学检查可见一个细胞性恶性梭形和上皮样肿瘤，伴有坏死区域和活跃的有丝分裂活性。在某些区域，肿瘤似乎形成了血管通道。存在局灶性骨肉瘤分化。进行了免疫组织化学研究，包括波形蛋白、平滑肌肌动蛋白、结蛋白、CD31、CD34、S100和泛细胞角蛋白。肿瘤细胞CD31和波形蛋白呈阳性，泛细胞角蛋白、CD34和S100呈阴性。术后两个月，患者存活且情况良好。
