Celik Eylem, Uzbay I Tayfun, Karakas Sirel
Hacettepe University, Specialization Area of Experimental Psychology, Ankara, Turkey.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jan;30(1):50-5. doi: 10.1016/j.pnpbp.2005.06.014. Epub 2005 Aug 9.
Sensitization development is linked to the addictive potential of the drugs. The same mechanisms might play a role in sensitization development to the different addictive drugs. The aim of the study was to investigate the development of cross-sensitization to caffeine and amphetamine in nicotine-induced locomotor sensitization in mice. Caffeine (2.5-20 mg/kg), amphetamine (1-16 mg/kg) or saline were injected to Swiss-Webster mice and locomotor activity was recorded for 30 min. Nicotine (0.5-2 mg/kg) or saline were injected to mice and locomotor activity was recorded for 30 min. Process was applied for 19 days, every other day (10 sessions). Caffeine (5 mg/kg), amphetamine (4 mg/kg) or saline were challenged to the different groups of nicotine-sensitized mice 2 days later on the last nicotine injection, and locomotor activity was recorded. Repetitive injections of nicotine (0.5-2 mg) produced locomotor sensitization in mice. After caffeine and amphetamine challenge injections, locomotor activity of the nicotine-sensitized mice was found to be significantly higher than saline-pretreated mice. Saline challenge did not produce any significant effect in nicotine- or saline-pretreated mice. Our results suggest that a cross-sensitization developed to both caffeine and amphetamine in nicotine-sensitized mice. In conclusion, similar central mechanisms may be responsible for the development of addiction to these substances.
致敏作用的发展与药物的成瘾潜力相关。相同的机制可能在对不同成瘾药物的致敏作用发展中发挥作用。本研究的目的是调查小鼠尼古丁诱导的运动致敏中对咖啡因和苯丙胺的交叉致敏作用的发展。向瑞士韦伯斯特小鼠注射咖啡因（2.5 - 20毫克/千克）、苯丙胺（1 - 16毫克/千克）或生理盐水，并记录30分钟的运动活动。向小鼠注射尼古丁（0.5 - 2毫克/千克）或生理盐水，并记录30分钟的运动活动。该过程持续19天，每隔一天进行一次（共10次）。在最后一次注射尼古丁两天后，对不同组的尼古丁致敏小鼠注射咖啡因（5毫克/千克）、苯丙胺（4毫克/千克）或生理盐水，并记录运动活动。重复注射尼古丁（0.5 - 2毫克）可使小鼠产生运动致敏。在注射咖啡因和苯丙胺激发剂后，发现尼古丁致敏小鼠的运动活动明显高于生理盐水预处理的小鼠。生理盐水激发对尼古丁或生理盐水预处理的小鼠没有产生任何显著影响。我们的结果表明，尼古丁致敏小鼠对咖啡因和苯丙胺均产生了交叉致敏。总之，类似的中枢机制可能是这些物质成瘾发展的原因。
