Wakabayashi K, Takahashi H, Obata K, Ikuta F
Department of Pathology, Niigata University, Japan.
Neurosci Lett. 1992 Apr 27;138(2):237-40. doi: 10.1016/0304-3940(92)90923-u.
We carried out an immunocytochemical examination of the brainstem and sympathetic ganglia of 5 autopsied patients with Parkinson's disease, using monoclonal antibodies against microtubule-associated protein 2 (MAP2) and synaptic vesicle-specific 38 kDa protein (SVP38). Lewy bodies (LBs) in the nerve cell somata were often immunoreactive for MAP2. Immunoreactivity of SVP38 in the somata of nerve cells was rarely demonstrated in the peripheral portion of the LBs. On the other hand, SVP38-immunoreactive (IR) LB-containing nerve cell processes were frequently found in the brainstem and sympathetic ganglia, considerably outnumbering MAP2-IR LB-containing nerve cell processes. These findings suggested that SVP38 is stored in LB-containing nerve cell processes and indicate that the majority of these processes are axons.
我们使用抗微管相关蛋白2（MAP2）和突触小泡特异性38 kDa蛋白（SVP38）的单克隆抗体，对5例帕金森病尸检患者的脑干和交感神经节进行了免疫细胞化学检查。神经细胞胞体中的路易小体（LBs）通常对MAP2呈免疫反应性。在路易小体的周边部分，很少显示神经细胞胞体中SVP38的免疫反应性。另一方面，在脑干和交感神经节中经常发现含有SVP38免疫反应性（IR）路易小体的神经细胞突起，其数量大大超过含有MAP2-IR路易小体的神经细胞突起。这些发现表明SVP38储存在含有路易小体的神经细胞突起中，表明这些突起大多数是轴突。
