Wakabayashi K, Takahashi H, Ohama E, Ikuta F
Department of Pathology, Niigata University, Japan.
Acta Neuropathol. 1990;79(6):581-3. doi: 10.1007/BF00294234.
We performed immunohistochemical analysis of specimens from three autopsied patients with Parkinson's disease, using antibodies to tyrosine hydroxylase (TH), vasoactive intestinal polypeptide (VIP), somatostatin, met-enkephalin, leu-enkephalin and substance P in an attempt to reveal the types of neurons that contain Lewy bodies (LBs) in the paravertebral and celiac sympathetic ganglia and in the enteric nervous system of the alimentary tract. In the sympathetic ganglia, almost all LB-containing neuronal cell bodies and processes were immunoreactive for TH. In the alimentary tract, however, most LBs were found in the VIP-immunoreactive (VIP-IR) neuronal cell bodies and processes. In spite of the significant presence of TH-IR neuronal cell bodies and processes in the alimentary tract, LB-containing TH-IR neuronal elements were rarely encountered. These findings indicate that in the alimentary tract, the VIP neuron system is mainly involved in the disease process of Parkinson's disease.
我们对三名帕金森病尸检患者的标本进行了免疫组织化学分析，使用针对酪氨酸羟化酶（TH）、血管活性肠肽（VIP）、生长抑素、甲硫氨酸脑啡肽、亮氨酸脑啡肽和P物质的抗体，试图揭示在椎旁和腹腔交感神经节以及消化道肠神经系统中含有路易小体（LB）的神经元类型。在交感神经节中，几乎所有含有LB的神经元细胞体和突起对TH呈免疫反应。然而，在消化道中，大多数路易小体见于VIP免疫反应性（VIP-IR）神经元细胞体和突起。尽管消化道中存在大量TH-IR神经元细胞体和突起，但很少遇到含有LB的TH-IR神经元成分。这些发现表明，在消化道中，VIP神经元系统主要参与帕金森病的疾病过程。
