Chk 1和Chk 2在缺氧和复氧中的作用。

The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation.

作者信息

Hammond Ester M, Freiberg Rachel A, Giaccia Amato J

机构信息

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University, Stanford, California 94303-5152, USA.

出版信息

Cancer Lett. 2006 Jul 18;238(2):161-7. doi: 10.1016/j.canlet.2005.06.029. Epub 2005 Aug 8.

DOI:10.1016/j.canlet.2005.06.029

PMID:16085356

Abstract

Both Chk 1 and Chk 2 are critically important checkpoint kinases. Chk 1 is an essential gene that is required for normal cell division and Chk 2 has been found to be mutated in an ever-growing list of human malignancies. Our recent studies indicate that both Chk 1 and Chk 2 have roles to play in the physiological stress of hypoxia/reoxygenation. Loss or inhibition of either kinase sensitizes cells to hypoxia/reoxygenation indicating that either or both could represent significant therapeutic targets.

摘要

Chk 1和Chk 2都是至关重要的检查点激酶。Chk 1是正常细胞分裂所必需的一个关键基因，并且已发现Chk 2在越来越多的人类恶性肿瘤中发生突变。我们最近的研究表明，Chk 1和Chk 2在缺氧/复氧的生理应激过程中均发挥作用。任一激酶的缺失或抑制都会使细胞对缺氧/复氧敏感，这表明其中之一或两者都可能是重要的治疗靶点。